RESET - Booklet - Manual / Resource - Page 18
Ketamine Works by 2 Major Pathways
The FIRST is the glycogen syntheses kinase-s (GSK-3) pathway, which results in the rapid antidepressant and anti-suicidal benefit of ketamine.
The SECOND pathway is actually much more important. Ketamine activates the production of brain-derived neurotrophic factor (BDNF), which is
the brain’s own repair inducer. Not only does ketamine increase BDNF, but it
also increases the number of receptors which BDNF binds. As a result, over
time, there is more repair factory and more receptors available to be activated
by the repair factor. The outcome is that over a period of weeks, neuroplasiiicity and repair occurs in the brain. This leads to reduction of depression, because depression is the result of the breakdown in circuits and damage to the
brain.”
-Theodore Henderson, MD, Dec 2018
https://www.psychiatryadvisor.com/home/topics/mood-disorders/depressive-disorder/painting-ketamine-in-a-bad-light/
